MDCAT 2026 inSee plans

MDCAT Biology Past Paper MCQs

Biology carries 45% of the MDCAT - 81 of 180 questions. Every item below comes from a real past paper.

77 questions16 chapters45% of the paper

Chapters by how often they are examined

Counted across every past paper in the archive. The top of this list is where marks are most reliably available. Anything PMDC dropped in the 2025 revision is marked, and sorted to the bottom - worth seeing for context, not worth revising.

  • Cell Structure & Function11 questions
  • Biological Molecules9 questions
  • Inheritance8 questions
  • Bioenergetics7 questions
  • Coordination & Control7 questions
  • Biotechnology6 questions
  • Support & Movement5 questions
  • Homeostasis4 questions
  • Immunity4 questions
  • Acellular Life3 questions
  • Circulation3 questions
  • Evolution3 questions
  • Enzymes2 questions
  • Digestion1 question
  • Reproduction1 question
  • Outside the current syllabusnot in the 2026 syllabus3 questions

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1Biologytemperature regulation

When the temperature of the body surrounding rises, baby responds by

  1. A.Vasoconstriction
  2. B.Vasodilation
  3. C.Shivering
  4. D.Raising body hairs

Answer and explanation locked

2Biologyurine concentration

The excretion of hypertonic urine in humans is associated best with the

  1. A.Glomerular capsule
  2. B.Proximal convoluted tubule
  3. C.Loop of henle
  4. D.Distal convoluted tubule

Answer and explanation locked

3Biologythermoregulation

In humans, the temperature regulation control conter is located in

  1. A.Kidneys
  2. B.Brain
  3. C.Lungs
  4. D.Liver

Answer and explanation locked

4Biologyliver functions

As an excretory organ, liver

  1. A.Detoxifies many chemical poisions
  2. B.Produces ammonia for excretion by the kidneys
  3. C.Produces uring and uric nitrogen of amino acids
  4. D.All of the above

Answer and explanation locked

5Biologyhormonal control of sodium

The active uptake of sodium in the ascending limb or thick loop of henle is promoted by the action of

  1. A.Aldosterone
  2. B.Thyroxine
  3. C.ADH
  4. D.Cortisone

Answer and explanation locked

6Biologymuscle types

Which of the following muscles are considered as ‘Voluntary Muscles’?

  1. A.Smooth muscles
  2. B.Crdiac muscles
  3. C.Skeletal muscles
  4. D.Glandular muscles

Answer and explanation locked

7Biologycardiac muscle

Which one of the following ‘myoenic’ types of muscle?

  1. A.Glandular muscles
  2. B.Cardiac muscles
  3. C.Skeletal muscles
  4. D.Smooth muscles

Answer and explanation locked

8Biologymuscle fiber terminology

What do we call the cell surface membrane of a muscle fiber?

  1. A.Sarcolemma
  2. B.Plasma membrane
  3. C.Sarcoplasm
  4. D.Myofibrils

Answer and explanation locked

9Biologyneurotransmitters

Which of the following neurotransmitters function, both as neurotransmitter and hormones, decreasing our perception of pain?

  1. A.Epinephrine
  2. B.Serotonin
  3. C.Dopamine
  4. D.Endorphins

Answer and explanation locked

10Biologyfeedback mechanisms

Which body function is controlled through positive feedback mechanism?

  1. A.Labor contractions
  2. B.Body temperature
  3. C.Insuliln production
  4. D.Thyroxin release

Answer and explanation locked

11Biologyneuron structure

Which of the following is common to all neurons?

  1. A.A cell which contains a nucleus
  2. B.A thick myelin heath
  3. C.Presence of node of Ranvier
  4. D.Presence of Schwann cells

Answer and explanation locked

12Biologyneuron structure

Neurons are cells adopted for the rapid transmission of electrical impulses. To do this, they have long thin process called:

  1. A.Axons
  2. B.Dendrited
  3. C.Myelin sheath
  4. D.Schwann cells

Answer and explanation locked

13Biologysynapse

___ is a junction between two neurons or between a motor neuron and a muscle cell

  1. A.Impulse
  2. B.Synapse
  3. C.Axon
  4. D.Cleft

Answer and explanation locked

14Biologymenstrual cycle

Which of the following represents the changes that occur in the ovary and the uterus approximately every 28 days involving evolution with the breakdown and loss of the linning of the uterus

  1. A.Ovulation
  2. B.Menstrual cycle
  3. C.Uterine cycle
  4. D.Embryo formation

Answer and explanation locked

15Biologysexually transmitted infections

Which of the following disease is sexually transmitted?

  1. A.Tuberculosis
  2. B.AIDs
  3. C.Dengue fever
  4. D.Cholera

Answer and explanation locked

16Biologypituitary hormones

Which of the following hormones of the pituitary gland regulate the menstrual cycle?

  1. A.Follicle stimulating bormone and estrogen
  2. B.Luteinizing hormone and estrogen
  3. C.Follicle stimumating hormone and luteinizing hormone
  4. D.Estrogen and progesterone

Answer and explanation locked

17Biologysex linked inheritance

Which traits ar most likely to affect men than women?

  1. A.X linked recessive
  2. B.X linked dominant
  3. C.Autosomal dominant
  4. D.Autosomal recessive

Answer and explanation locked

18Biologymodes of inheritance

Alleles both have an effect on the phenotype heterozygotic organism

  1. A.Dominant
  2. B.Recessive
  3. C.Multiple
  4. D.Co-dominant

Answer and explanation locked

19Biologyhomozygosity and heterozygosity

When both the allele of a genes are same, the organism is said to be:

  1. A.Heterozygous
  2. B.Genotype
  3. C.Homozygous
  4. D.Phenotype

Answer and explanation locked

20Biologycell wall presence

In which type of cell. Cell wall is not present?

  1. A.Plant cells
  2. B.Fungal cells
  3. C.Bacterial cells
  4. D.Liver cells

Answer and explanation locked

21Biologyribosome size

70S size ribosomes are found in the cells of

  1. A.Algae
  2. B.Protozoans
  3. C.Fungi
  4. D.Bacteria

Answer and explanation locked

22Biologyfluid mosaic model

According to the fluid mosaic model of cell membrane, which zone is embedded inside?

  1. A.Hydrophobic
  2. B.Globular
  3. C.Hydrophilic
  4. D.Filamentous

Answer and explanation locked

23Biologytonoplast

The membrane separating the vacuole from cytoplasm is called

  1. A.Cristae
  2. B.Cisternae
  3. C.Tonoplast
  4. D.Vacuolar membrane

Answer and explanation locked

24Biologysmooth er functions

Select the one which is not a function of smooth endoplasmic retidulum (SER)?

  1. A.Metabolism of lipids
  2. B.Transmission of impulses
  3. C.Transport of materails
  4. D.Processing og glycoproteins

Answer and explanation locked

25Biologycell wall synthesis

Which of the following organelles are involves in the synthesis of plant cell wall?

  1. A.Endoplasmic reticulum
  2. B.Golgi complex
  3. C.Lysosomes
  4. D.Peroxisomes

Answer and explanation locked

26Biologymembrane integrity

Which property of water helps to maintain the integrity of cell membrances?

  1. A.Specific heat capacity
  2. B.Hydrogen bonding
  3. C.Cohesion and adhesion
  4. D.Hydrophobic exclusion

Answer and explanation locked

27Biologysolvent properties

Water act as universal solvent because of

  1. A.Heat of vaporization
  2. B.Hydrogen bonding
  3. C.High polarity
  4. D.Cohesion and adhesion

Answer and explanation locked

28Biologyenergy content

Lipids store double amount of energy as compared to carbohydrtes because of

  1. A.High proportion of oxygen
  2. B.High C-O ratio
  3. C.Low proportion of carbon
  4. D.High proportion of C-H

Answer and explanation locked

29Biologyfatty acids

Which of the following is an unsaturated fatty acid?

  1. A.Oleic acid
  2. B.Palmitic acid
  3. C.Butyric acid
  4. D.Acetic acid

Answer and explanation locked

30Biologynad

NAD is an example of

  1. A.Mononucleotide
  2. B.Dinucleotide
  3. C.Tri nucleotide
  4. D.Tetra cucleotide

Answer and explanation locked

31Biologyenzyme conditions

Most enzymes have and optimum temperature of around

  1. A.30oC
  2. B.40oC
  3. C.50oC
  4. D.20oC

Answer and explanation locked

32Biologyenzyme catalysis

Enzymes work by lowering the ___ of the reactions that catalyze

  1. A.Kinetic energy
  2. B.Activation energy
  3. C.Heat energy
  4. D.Potential energy

Answer and explanation locked

33Biologycalvin cycle

First stable compound during calvin cycle is

  1. A.3-phosphoglycerate
  2. B.Glyceraldehyde 3-phosphatse
  3. C.1,3 bisphosphoglyceratae
  4. D.Ribulose biphosphate

Answer and explanation locked

34Biologyribulose

What is the function of ribulose?

  1. A.Intermediate in photosynthesis
  2. B.Respirator fuel
  3. C.Intermediate in cellular respiration
  4. D.Component of DNA and RNA

Answer and explanation locked

35Biologypyruvate

Which of the following process does not need pyruvic acid as a substrate?

  1. A.Alcohol dermentation
  2. B.Calvin cycle
  3. C.Aerobic respiration
  4. D.Lactic acid dermentation

Answer and explanation locked

36Biologyelectron transport chain

Which of the following is a copper containing protein in electron transport chain?

  1. A.Plastoquinone
  2. B.Cytochrome-C
  3. C.Plastocyanin
  4. D.Ferrodoxin

Answer and explanation locked

37Biologyelectron transport chain

In electron transport chain, ATP synthesis takes place when electron moves from

  1. A.Primary electron acceptor (PEA) to plastoquinone
  2. B.Plastoquinone (Pq) to cytochromes
  3. C.Cytochromes to plastocyanin
  4. D.Plastocyanin (Pc) to photosystem 1 (PS-I)

Answer and explanation locked

38Biologymendelian genetics

“law of independent assortment” states

  1. A.The each pari of alleles assort independent of other pairs of alleles during gamete formation
  2. B.That allele fo each pair of constrasting trait have unequal probability to assort with the alleles of other pairs
  3. C.That that coexisting alleles for each trait segregate (separate) from each other at meiosis so that each gamete receives only one of the two alleles
  4. D.That pertain to inheritance of single trait (monohybrid cross)

Answer and explanation locked

39Biologybasic terms

Phenotype is

  1. A.The genetic complement ie the genes in an individual for a particulartrait
  2. B.Partner of gene pair
  3. C.The form of appearance of a trait
  4. D.The position of a gene on the chromosome

Answer and explanation locked

40Biologydominance

In complete dominance

  1. A.Differendt alleles of a gene are both expressesed in heterozygous condition
  2. B.One alleles (R) is completely dominant over the other (r) and the presence of recessive allele is functionally hidden the heterozygote (Rr) has the same sound phenotype (RR) heterozygote
  3. C.The phenotype of the heterozygote is intermediate between phenotypes of the homozygotes
  4. D.Gene mutation may produce many different alleles of a gene

Answer and explanation locked

41Biologynucleic acids

Which one of the following is found both messgenger RNA an DNA of a mammalian cell?

  1. A.Double helical structure
  2. B.Ribose sugar
  3. C.Thymine
  4. D.Sugar- phosphate backbone

Answer and explanation locked

42Biologygerm line vs somatic

The cells in our body are all genetically identical apart from the

  1. A.Somatic cells
  2. B.Reproductive cells
  3. C.Muscle fibers
  4. D.White blood cells

Answer and explanation locked

43Biologytranscription

Transcription is the process in which an RNA copy of the DNA sequence and coding the gene is produced with help of an enzyme called:

  1. A.DNA polymerases
  2. B.RNA polymerase
  3. C.DNA transcriptase
  4. D.RNA trnscriptase

Answer and explanation locked

44Biologykaryotype

Th particular array of chromosomes that an individual prossess is called its

  1. A.Genotype
  2. B.Phenotype
  3. C.Karyotype
  4. D.Allele

Answer and explanation locked

45Biologymeiosis

During meiosis, the homologous chromosomes comes together and form pairs this process is called

  1. A.Linkage
  2. B.Synapsis
  3. C.Pairing
  4. D.Crossing over

Answer and explanation locked

46Biologydna replication

At what phase the DNA content of a cell is doubled?

  1. A.Prophase
  2. B.Interphase
  3. C.Anaphase
  4. D.Telophase

Answer and explanation locked

47Biologytranscription

Which statement correctly describes transcription of DNA?

  1. A.It produces aminon acids
  2. B.It produces messenger RNA
  3. C.It results in increased DNA synthesis
  4. D.It is a semi conservative process

Answer and explanation locked

48Biologyendosymbiont theory

This theory says that “mitochondria and chloroplast area in effect ancient bacteria which now live inside the large cells”

  1. A.Darwin’s theory of evolution
  2. B.Lamarckism
  3. C.Neo-darwinsm
  4. D.Endosymbiont theory

Answer and explanation locked

49Biologyanalogous vs homologous

The organs which are similar but differ in structure are called

  1. A.Analogous organs
  2. B.Homologous organs
  3. C.Convergent evolution
  4. D.Divergent evolution

Answer and explanation locked

50Biologynatural selection

____ occurs because natural selection gives some alleles a batter chance of survival than others

  1. A.Fitness
  2. B.Evolution
  3. C.Crossing over
  4. D.Artificial selection

Answer and explanation locked

51Biologyrecombinant dna

The DNA that has been altered and which now contains length of nucleotides from two different organisms is called a

  1. A.Plasmid
  2. B.Combined DNA
  3. C.Vector
  4. D.Recombinant DNA

Answer and explanation locked

52Biologypcr

It is a method for rapid production of a very large number of copies of a particular fragment of DNA

  1. A.Gel electrophoresis
  2. B.Polymerase chain reaction
  3. C.DNA extraction
  4. D.Recombination

Answer and explanation locked

53Biologydna ligase

What is the effect of DNA ligase?

  1. A.DNA is broken up at specific sits
  2. B.DNA fragments are joined together
  3. C.DNA replication occurs
  4. D.DNA transcription occurs

Answer and explanation locked

54BiologyrDNA tools

Which of the following is the components/ tools of recombinant DNA technology?

  1. A.Gene of interest
  2. B.Molecular scissors
  3. C.Molecular glue and expression system
  4. D.All of the above

Answer and explanation locked

55Biologygel electrophoresis

Gel electrophoresis is a technique

  1. A.Employed by forensic scientists to assist in the identification of the individuals by their respective type of DNA
  2. B.Collect all the genes found in one complete set of chromosomes
  3. C.Is a technique to separate different size fragment of charge bearing polymers (proteins, RNA or DNA)
  4. D.Grows single cells of a group of cells in a glass ware on artificial medium under aseptic conditions

Answer and explanation locked

56Biologytransgenic organisms

Transgenic organisms

  1. A.Havae a foreigh gene inserted into them
  2. B.Have an important role in the large scale production of medicinal products
  3. C.Are considered beneficial to humans
  4. D.All of the above

Answer and explanation locked

57Biologypcr reagents

Which of the following is not necessary for PCR to occur?

  1. A.dATP
  2. B.primers
  3. C.DNA fragments
  4. D.Ribonucleotides

Answer and explanation locked

58Biologyglycolysis

The end product of glycolysis in acrobic respiration is

  1. A.Ethanol and carbon dioxide
  2. B.Lactate
  3. C.Pyruvate
  4. D.Acetyl CoA

Answer and explanation locked

59Biologyviruses

Which of the following is not related enveloped virus?

  1. A.They survive for a short time
  2. B.Their envelop is sensitive to sunlight
  3. C.They are tolerant to antidotes
  4. D.Envelop is derived from host

Answer and explanation locked

60Biologyaids

Numerous opportunistic diseases might attack a persone suffering from which of the following disease?

  1. A.Measles
  2. B.Influenza
  3. C.Hepatitits A
  4. D.AIDS

Answer and explanation locked

61Biologyvirion

The complete, mature and infection virus particle is known as

  1. A.Venome
  2. B.Genome
  3. C.Virion
  4. D.Capsid

Answer and explanation locked

62Biologyhiv

Which of the following is not TRUE about Human Immunodeficiency virus ( HIV)?

  1. A.It is retrovirus
  2. B.It is surrounded by an envelop
  3. C.It does not cause AIDS
  4. D.It causes the deficiency of the human immune system

Answer and explanation locked

63Biologysterilization methods

Select a method which cause the oxidation of constituent of a bacterial cell

  1. A.Steam
  2. B.Filtration
  3. C.Dry heat
  4. D.Radiation

Answer and explanation locked

64Biologybacterial structure

Which of the following is TRUE about the structure if typical bacterium?

  1. A.It has a cell wall
  2. B.It has cytoplasm
  3. C.It has genetic material
  4. D.All of the above

Answer and explanation locked

65Biologyred algae

Red algae do not contribute towards

  1. A.Making coral reefs
  2. B.Forming limestone deposits
  3. C.Making fertilizers
  4. D.Forming chalk deposits

Answer and explanation locked

66Biologyamoeba

Which of the following is true about amoeba?

  1. A.They havae flagella
  2. B.They are multicellular
  3. C.They do not cause any disease in humans
  4. D.They move by forming specialized cytoplasmic projections called pseudopodia

Answer and explanation locked

67Biologytaxis

The directional movement toward or away from the stimulus is called

  1. A.Tropism
  2. B.Orientation
  3. C.Taxis
  4. D.Non orientation

Answer and explanation locked

68Biologythylakoid

Photophosphorylation takes place in the ____ of the chloroplasts

  1. A.Stroma
  2. B.Granum
  3. C.Inner membrane
  4. D.Outer membrane

Answer and explanation locked

69Biologyanamniotes

Select an anamniote from the following

  1. A.Snake
  2. B.Frog
  3. C.Parrot
  4. D.Crocodile

Answer and explanation locked

70Biologywater transport

In roots the apoplast pathway of water is disrupted when water reaches

  1. A.Plasmodesmata
  2. B.Cortex
  3. C.Endodermis
  4. D.Pith

Answer and explanation locked

71Biologyheart structure

Regarding structure of human heart chordae tendinea are present in

  1. A.Atria
  2. B.Pulmonary valvea
  3. C.Ventricles
  4. D.Aortic valve

Answer and explanation locked

72Biologycardiovascular system

The only vein in human body carrying oxygenated blood is

  1. A.Femoral
  2. B.Pulmonary
  3. C.Renal
  4. D.Iliac

Answer and explanation locked

73Biologylymphocytes

The cells which play very important in developing immunity are

  1. A.Monocytes
  2. B.Neutrophils
  3. C.Lymphocytes
  4. D.Thrombocytes

Answer and explanation locked

74Biologyblood pressure

Which of the following blood vessels have the highest pressure of blood?

  1. A.Aorta
  2. B.Pulmonary arteries
  3. C.Pulmonary veins
  4. D.Vena cava

Answer and explanation locked

75Biologyautoimmunity

Autoimmune disease act at the principle of

  1. A.Self against antigens
  2. B.Antigens against self
  3. C.Self against self
  4. D.Antigens self-dstroyed

Answer and explanation locked

76Biologyheart chambers

In human heart, the left atrium receives

  1. A.The superior Vena Cava
  2. B.The inferior Vena Cava
  3. C.The coronary sinus
  4. D.The four pulmonary veins

Answer and explanation locked

77Biologyantibodies

Antibodies are manufactured in

  1. A.T lymphocytes
  2. B.Red blood cells
  3. C.Platelets
  4. D.B lymphocytes

Answer and explanation locked